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The Optimization of a Novel, Weak Bromo and Extra Terminal

terminal bet Discussion. This study describes a mechanism by which inhibition of a specific BET bromodomain reduces NOS2 transcription and β-cell dysfunction. BET inhibitors are a class of drugs that reversibly bind the bromodomains of Bromodomain and Extra-Terminal motif proteins BRD2, BRD3, BRD4, and BRDT

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